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Sigma
Big Endothelin 38 human
E9387 -
≥95% (HPLC)
DOWNLOAD MSDS (PDF)CAS Number: 120796-97-6
Empirical Formula (Hill Notation): C189H282N48O56S5
Molecular Weight: 4282.87
MDL number: MFCD00081408
Properties
| Related Categories | Application Index, Cell Signaling Enzymes, Chymase and Related Products, Endothelins, Peptides for Cell Biology, |
| assay | ≥95% (HPLC) |
| storage temp. | −20°C |
| Gene Information | Research your gene in Your Favorite Gene powered by Ingenuity human ... EDN1(1906) |
Description
Amino Acid Sequence
Cys-Ser-Cys-Ser-Ser-Leu-M
Biochem/physiol Actions
Precursor of endothelin 1; vasoconstrictor activity appears to be due to its conversion to endothelin 1 by endothelin converting enzyme in the tissue.
Price and Availability
Safety Information
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
Technical information & documentation associated with this product is available in the Safety & Documentation tab.
References
Burkhardt, M., Receptor- and non-receptor-mediated clearance of big-endothelin and endothelin-1: differential effects of acute and chronic ETA receptor blockade. J. Hypertens. 18, 273, (2000) Abstract
Schilling, L., et al., Characterization of the contractile and relaxant action of the endothelin-1 precursor, big endothelin-1, in the isolated rat basilar artery. Peptides 21, 91-99, (2000) Abstract
Yap, E.Y., et al., Contraction to big endothelin-1 big endothelin-2 and big endothelin-3 and endothelin-converting enzyme inhibition in human isolated bronchi. Br. J. Pharmacol. 129, 170-176, (2000) Abstract
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